In Vivo GABA Increase as a Biomarker of the Epileptogenic Zone: an Unbiased Metabolomics Approach

Florence Fauvelle, Vasile Stupar, Jia Guo, Wafae Labriji, Chen Liu, Alicia Plaindoux, Emmanuel Luc Barbier, Sophie Hamelin, Antoine Depaulis
May, 2021
Cite ISMRM

Abstract

New non invasive methods are required to better delimit the epileptogenic zone (EZ) during the pre-surgical exam of epileptic patients. By combining ex vivo NMR spectroscopy-based (MRS) untargeted metabolomics and in vivo MRS-based targeted metabolomics, we found that GABA was the most discriminant metabolite of the epileptogenic zone vs adjacent brain regions in a mouse model of mesio-temporal lobe epilepsy (MTLE). GABA appears therefore as a specic in vivo biomarker of EZ in MTLE.

Type
Conference paper
Publication
In International Society for Magnetic Resonance in Medicine (ISMRM) 1-Page Abstract
abstract
Chen Liu
Chen Liu
PhD Student in Computer Science

Researcher in machine learning and healthcare.