In vivo γ‐aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach

Sophie Hamelin, Vasile Stupar, Lucile Mazière, Jia Guo, Wafae Labriji, Chen Liu, Ludiwine Bretagnolle, Sandrine Parrot, Emmanuel L Barbier, Antoine Depaulis, Florence Fauvelle
December, 2020
PDF Cite Wiley Commentary on Epilepsy Currents

Abstract

Following surgery, focal seizures relapse in 20% to 50% of cases due to the difficulty of delimiting the epileptogenic zone (EZ) by current imaging or electrophysiological techniques. Here, we evaluate an unbiased metabolomics approach based on ex vivo and in vivo nuclear magnetic resonance spectroscopy (MRS) methods to discriminate the EZ in a mouse model of mesiotemporal lobe epilepsy (MTLE).

Type
Journal article
Publication
In Epilepsia
Chen Liu
Chen Liu
PhD Student in Computer Science

Researcher in machine learning and healthcare.