In Vivo GABA Increase as a Biomarker of the Epileptogenic Zone: an Unbiased Metabolomics Approach


New non invasive methods are required to better delimit the epileptogenic zone (EZ) during the pre-surgical exam of epileptic patients. By combining ex vivo NMR spectroscopy-based (MRS) untargeted metabolomics and in vivo MRS-based targeted metabolomics, we found that GABA was the most discriminant metabolite of the epileptogenic zone vs adjacent brain regions in a mouse model of mesio-temporal lobe epilepsy (MTLE). GABA appears therefore as a specic in vivo biomarker of EZ in MTLE.

In International Society for Magnetic Resonance in Medicine (ISMRM) 1-Page Abstract
Chen Liu
Chen Liu
PhD Student in Computer Science

Researcher in machine learning and healthcare.