Substituting Gadolinium In Human Brain MRI Using DeepContrast


MRI estimation of cerebral blood volume (CBV) is useful in mapping potential brain function. To obtain high-resolution CBV maps, it typically requires intravenous (IV) injections of Gadolinium-based contrast agents (GBCAs), the use of which has come under new scrutiny. Here, we design and implement a deep learning algorithm, DeepContrast, to estimate GBCA contrast directly from T1-weighted (T1W) structural MRI. The predicted contrast performs equally well as the GBCA-enhanced CBV map even in mapping subtle age-related functional changes in the human brain. Therefore, our study demonstrates the feasibility of substituting GBCA in human brain MRI using DeepContrast.

In International Society for Magnetic Resonance in Medicine (ISMRM) 1-Page Abstract Oral Power Pitch
Chen Liu
Chen Liu
PhD Student in Computer Science

Researcher in machine learning and healthcare.